emphysema

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	179
interventional	122
Observational	49
Registry	8

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Device	26
Drug|placebo	19
Behavioral	15
Drug	13
Other	12
Procedure	12
Biological	7
Device|Other	4
Biological|placebo	3
Behavioral|Device	2
Behavioral|Other	1
Biological|Drug	1
Biological|Other	1
Device|placebo	1
Device|Procedure	1
Diagnostic Test|Drug|placebo	1
Drug|Genetic|Procedure	1
Drug|Other|placebo	1
Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	50
NA	6
Canada	5
Germany	5
Netherlands	5
United Kingdom	5
Brazil	3
Spain	3
Austria|Germany|Netherlands	2
China	2
Denmark	2
France	2
Germany|Netherlands	2
Israel	2
United States|Canada	2
United States|Puerto Rico	2
Australia|Austria|Germany|Ireland	1
Australia|Austria|Germany|Ireland|New Zealand|United Kingdom	1
Australia|Brazil|Germany	1
Australia|Canada|Czech Republic|Denmark|Estonia|Finland|Germany|Ireland|Poland|Romania|Sweden	1
Austria|France|Germany|Israel	1
Austria|France|Germany|Italy|Netherlands|United Kingdom	1
Belgium|France|Germany|Netherlands|Sweden|United Kingdom	1
Bulgaria|Germany|Hungary|Ukraine	1
Canada|Denmark|Germany|Ireland|Netherlands|Sweden|United Kingdom	1
Colombia	1
Denmark|Sweden|United Kingdom	1
Egypt	1
France|Germany|Netherlands	1
Italy	1
Japan|	1
Korea, Republic of	1
Netherlands|United Kingdom	1
Turkey	1
United States|Argentina|Australia|Brazil|Canada|Denmark|Estonia|France|Germany|New Zealand|Poland|Romania|Russian Federation|Spain|Sweden	1
United States|Australia|Canada|Czech Republic|Denmark|Estonia|Finland|Germany|Ireland|Poland|Romania|Russian Federation|Sweden	1
United States|Australia|Canada|Denmark|Estonia|New Zealand|Poland|Sweden	1
United States|Belgium|Canada|Denmark|Poland|Spain|Sweden|United Kingdom	1
United States|Brazil|Netherlands|United Kingdom	1
United States|Bulgaria|Czech Republic|Hungary|Iceland|Israel|Italy|Latvia|Poland|South Africa|Ukraine|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	63
2	12
3	5
4	2
5	6
6	4
8	5
9	1
10	1
11	1
12	2
14	1
17	2
19	1
21	1
22	1
23	1
26	1
28	3
34	2
48	1
60	1
64	1
65	1
90	1
93	1
97	1

Phase

Phase	Study_Count
N/A	51
Phase 2	24
Phase 4	14
Phase 3	12
Phase 1	9
Phase 1/Phase 2	6
Phase 2/Phase 3	6

Number of Arms

Number_of_Arms	Count_of_Studies
1	36
2	58
3	10
4	2
5	1
NA	15

Enrollment Metrics by Phase

Measure	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	4.00	6.00000	8.00	10.00000	10.0000	22.0000	12
1st Qu.	24.00	10.00000	19.00	20.00000	30.0000	82.5000	50
Median	60.50	15.00000	30.50	38.00000	114.0000	270.0000	93
Mean	149.98	19.88889	33.50	74.71429	137.8333	303.5455	111
3rd Qu.	148.50	25.00000	50.25	91.00000	224.2500	391.0000	170
Max.	3000.00	47.00000	60.00	491.00000	326.0000	799.0000	240

Trial Group Type

group_type	Group_Count
Experimental	103
Active Comparator	45
Placebo Comparator	26
NA	15
No Intervention	13
Other	6
Sham Comparator	2

Intervention Model

intervention_model	Study_Count
Parallel Assignment	65
Single Group Assignment	46
Crossover Assignment	6
NA	5

Primary Purpose

primary_purpose	Study_Count
Treatment	98
Basic Science	7
Diagnostic	6
Supportive Care	4
Other	2
Prevention	2
NA	2
Health Services Research	1

Observational Studies

Studies by Country

Country	Study_Count
United States	19
United Kingdom	11
NA	5
Belgium	3
Germany	2
Italy	2
Sweden	2
China	1
France	1
Israel	1
Netherlands	1
United States|Belgium|Canada|Denmark|Finland|Germany|Japan|Korea, Republic of|Poland|Spain|Sweden|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	36
2	7
5	1
6	1
12	1
21	1
25	1
51	1

Enrollment Metrics

Measure	Observational
Min	2.0000
1st Qu	60.0000
Median	131.0000
Mean	484.9333
3rd Qu	300.0000
Max	10500.0000

Observation Model

observational_model	Study_Count
Cohort	24
Case-Control	7
Case-Only	6
NA	6
Case Control	3
Other	2
Case-Crossover	1

Time Perspective

time_perspective	Study_Count
Prospective	32
Cross-Sectional	11
NA	5
Retrospective	1

Registries

Studies by Country

Country	Study_Count
United States	5
Austria|Germany|Switzerland	1
Germany|Switzerland|United Kingdom	1
Korea, Republic of	1

Sites per Study

Site_count	Study_Count
1	4
2	2
3	1
21	1

Enrollment Metrics

Measure	Registries
Min	2.00
1st Qu	56.50
Median	105.00
Mean	9827.25
3rd Qu	975.00
Max	75000.00

Registry Model

observational_model	Study_Count
Cohort	4
Case-Only	2
Case-Control	1
Other	1

Time Perspective

time_perspective	Study_Count
Other	3
Prospective	3
Cross-Sectional	2

Follow-up

target_duration	Study_Count
2 Months	2
1 Year	1
15 Years	1
2 Years	1
3 Months	1
3 Years	1
5 Years	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03382106	Smoking Cessation and Functional CT Assessment	https://ClinicalTrials.gov/show/NCT03382106	Recruiting	University of Iowa	2023-02-28
NCT03360396	Study of PneumRx Endobronchial Coil System in Treatment of Subjects With Severe Emphysema	https://ClinicalTrials.gov/show/NCT03360396	Active, not recruiting	PneumRx, Inc.	2020-04-30
NCT03205826	Chartis Collateral Ventilation Measurement: Conscious Sedation Versus General Anesthesia	https://ClinicalTrials.gov/show/NCT03205826	Completed	University Medical Center Groningen	2019-01-22
NCT03114020	Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency	https://ClinicalTrials.gov/show/NCT03114020	Completed	Turino, Gerard, M.D.	2019-11-12
NCT03073798	The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis	https://ClinicalTrials.gov/show/NCT03073798	Completed	Johns Hopkins University	2015-05-14
NCT03010449	LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves	https://ClinicalTrials.gov/show/NCT03010449	Recruiting	Royal Brompton & Harefield NHS Foundation Trust	2020-02-29
NCT03008915	Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency	https://ClinicalTrials.gov/show/NCT03008915	Active, not recruiting	Columbia University	2018-07-31
NCT02999685	Home-based Health Management of Chronic Obstructive Lung Disease (COPD) Patients	https://ClinicalTrials.gov/show/NCT02999685	Completed	Mayo Clinic	2019-06-30
NCT02935452	Implementing and Evaluating the Genie Tool in COPD	https://ClinicalTrials.gov/show/NCT02935452	Completed	University of Southampton	2017-11-30
NCT02914340	REACH SVS Control Patient Cross-Over Study	https://ClinicalTrials.gov/show/NCT02914340	Completed	Spiration, Inc.	2017-06-30
NCT02879331	Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils	https://ClinicalTrials.gov/show/NCT02879331	Recruiting	Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz	2021-09-30
NCT02877459	Clinical Investigation of a Modified Staged Treatment Algorithm Using the AeriSeal System	https://ClinicalTrials.gov/show/NCT02877459	Completed	Pulmonx Corporation	2017-11-16
NCT02796937	Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency	https://ClinicalTrials.gov/show/NCT02796937	Enrolling by invitation	Grifols Therapeutics LLC	2025-12-31
NCT02713347	Advancing Symptom Alleviation With Palliative Treatment	https://ClinicalTrials.gov/show/NCT02713347	Recruiting	VA Office of Research and Development	2020-12-31
NCT02696564	Losartan Effects on Emphysema Progression	https://ClinicalTrials.gov/show/NCT02696564	Active, not recruiting	JHSPH Center for Clinical Trials	2021-03-31
NCT02687997	Prevalence of Sleep Disordered Breathing in a Lung Cancer Screening Cohort	https://ClinicalTrials.gov/show/NCT02687997	Completed	Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz	2017-07-31
NCT02682147	Functional CT Assessment of Pulmonary Arterial Dysfunction in Smoking Associated Emphysema	https://ClinicalTrials.gov/show/NCT02682147	Recruiting	University of Iowa	2023-02-28
NCT02633293	An Open Label Extension Study to Evaluate Inhaled Treprostinil in Adult PH With ILD Including CPFE	https://ClinicalTrials.gov/show/NCT02633293	Active, not recruiting	United Therapeutics	2022-11-30
NCT02630316	Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE	https://ClinicalTrials.gov/show/NCT02630316	Completed	United Therapeutics	2019-12-26
NCT02399514	Improvement of Sleep Quality by RePneu® Coils in Advanced Pulmonary Emphysema	https://ClinicalTrials.gov/show/NCT02399514	Completed	Institut für Pneumologie Hagen Ambrock eV	2018-03-09
NCT02382367	Prevalence of Alpha-1 Antitrypsin Dysfunction in Pulmonary Emphysema	https://ClinicalTrials.gov/show/NCT02382367	Completed	Hospices Civils de Lyon	2015-12-31
NCT02179125	Identifying REsponders and Exploring Mechanisms of ACTION of the Endobronchial Coil Treatment for Emphysema	https://ClinicalTrials.gov/show/NCT02179125	Completed	University Medical Center Groningen	2019-07-31
NCT02107209	Low Cost Biological Lung Volume Reduction Therapy for Advanced Emphysema	https://ClinicalTrials.gov/show/NCT02107209	Completed	Mansoura University	2015-04-30
NCT02099799	The Effect of Physical Activity Promotion on Short and Long-term Outcomes in COPD	https://ClinicalTrials.gov/show/NCT02099799	Completed	VA Office of Research and Development	2019-11-01
NCT01306513	Safety and Feasibility Study of Administration of Mesenchymal Stemcells for Treatment of Emphysema	https://ClinicalTrials.gov/show/NCT01306513	Completed	Leiden University Medical Center	2012-06-30
NCT02042976	Mindfulness-based Cognitive Therapy for Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT02042976	Completed	University of Aarhus	2016-09-30
NCT02012673	A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System.	https://ClinicalTrials.gov/show/NCT02012673	Completed	University Medical Center Groningen	2016-09-30
NCT02006576	Prostaglandin Inhibition for Emphysema	https://ClinicalTrials.gov/show/NCT02006576	Completed	University of Nebraska	2018-03-31
NCT01989182	The Spiration Valve System for the Treatment of Severe Emphysema	https://ClinicalTrials.gov/show/NCT01989182	Completed	Spiration, Inc.	2016-05-18
NCT01949181	Blood, Hair and Lung Concentrations of Metals and Metalloids in Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT01949181	Completed	Hopital Foch	2014-03-31
NCT01872624	Safety Study of Bone-marrow Derived Mesenchymal Stromal Cells Associated With Endobronchial Valves in Emphysema	https://ClinicalTrials.gov/show/NCT01872624	Completed	Hospital de Clinicas de Porto Alegre	2014-12-31
NCT01869205	The Effect and Mechanism of Bronchoscopic Lung Volume Reduction by Endobronchial Valve in Korean Emphysema Patients	https://ClinicalTrials.gov/show/NCT01869205	Completed	Asan Medical Center	2014-04-30
NCT01860898	A Phase I Study of iPS Cell Generation From Patients With COPD	https://ClinicalTrials.gov/show/NCT01860898	Active, not recruiting	Mayo Clinic	2021-01-31
NCT01812447	Evaluation of the Spiration® Valve System for Emphysema to Improve Lung Function	https://ClinicalTrials.gov/show/NCT01812447	Active, not recruiting	Spiration, Inc.	2017-11-30
NCT01796392	Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)	https://ClinicalTrials.gov/show/NCT01796392	Active, not recruiting	Pulmonx Corporation	2017-09-30
NCT02025205	Improving Patient Outcomes by Selective Implantation of the Zephyr EBV - Study	https://ClinicalTrials.gov/show/NCT02025205	Completed	Pulmonx Corporation	2016-04-30
NCT01744093	Doxycycline for COPD in HIV-Infected Patients	https://ClinicalTrials.gov/show/NCT01744093	Active, not recruiting	Weill Medical College of Cornell University	2017-10-25
NCT01731015	Imaging Lung Function Using Oxygen Enhanced MRI	https://ClinicalTrials.gov/show/NCT01731015	Completed	Duke University	2012-09-30
NCT01719263	Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study	https://ClinicalTrials.gov/show/NCT01719263	Completed	Uptake Medical Corp	2015-10-31
NCT01710449	Evaluation of Regional Ventilation Using 19F MRI of Inert Perfluorinated Gases Mixed With Oxygen	https://ClinicalTrials.gov/show/NCT01710449	Completed	Duke University	2012-10-31
NCT01682850	Pulmonary Rehabilitation Before Lung Cancer Resection	https://ClinicalTrials.gov/show/NCT01682850	Completed	Mayo Clinic	2018-12-31
NCT01615484	Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant Suitability	https://ClinicalTrials.gov/show/NCT01615484	Completed	University of North Carolina, Chapel Hill	2016-03-31
NCT01528267	Bronchoscopic Lung Volume Reduction Using Blood	https://ClinicalTrials.gov/show/NCT01528267	Completed	Chelsea and Westminster NHS Foundation Trust	2013-03-31
NCT01495780	eRT Remote Health Monitoring	https://ClinicalTrials.gov/show/NCT01495780	Completed	University of California, Los Angeles	2014-08-20
NCT01421082	Evaluation of Physiologic Parameters to Study the Mechanism of Action of the Lung Volume Reduction Coil in Subjects With Homogeneous Emphysema	https://ClinicalTrials.gov/show/NCT01421082	Completed	PneumRx, Inc.	2013-03-31
NCT01336283	Effectiveness of Different Exercise Training Programs to the Profile of COPD Patients	https://ClinicalTrials.gov/show/NCT01336283	Completed	Hospitales Universitarios Virgen del Rocío	2010-12-31
NCT01334307	Randomized Comparison of the RePneu Lung Volume Reduction Coil (LVRC) to Standard of Care for the Treatment of Emphysema (RESET Study)	https://ClinicalTrials.gov/show/NCT01334307	Completed	PneumRx, Inc.	2013-06-30
NCT01328899	Feasibility Study of PneumRx’s Lung Volume Reduction Coil (LVRC)	https://ClinicalTrials.gov/show/NCT01328899	Completed	PneumRx, Inc.	2013-01-31
NCT04347044	The Effect of Pulmonary Rehabilitation on Bronchoscopic Volume Reduction Process Success	https://ClinicalTrials.gov/show/NCT04347044	Active, not recruiting	Istanbul Medipol University Hospital	2019-03-01
NCT03837847	Mechanistic Effects of Health Coaching to Reduce COPD Hospitalizations	https://ClinicalTrials.gov/show/NCT03837847	Recruiting	Mayo Clinic	2022-08-31
NCT03836547	Feasibility of a Multi Component Intervention in Patients With Severe Dyspnea and Obesity	https://ClinicalTrials.gov/show/NCT03836547	Enrolling by invitation	Mayo Clinic	2021-12-01
NCT03814980	A Home-based Intervention to Promote Mindful Breathing Awareness Through Pursed-lip Breathing Training for COPD Patients	https://ClinicalTrials.gov/show/NCT03814980	Completed	Mayo Clinic	2019-08-30
NCT03685526	Cinenses Lung Volume Reduction Reverser System First-in-man Study Treating Patients With Severe Emphysema	https://ClinicalTrials.gov/show/NCT03685526	Recruiting	Lifetech Scientific (Shenzhen) Co., Ltd.	2020-05-31
NCT03679598	Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency	https://ClinicalTrials.gov/show/NCT03679598	Recruiting	University of Alabama at Birmingham	2021-08-31
NCT03673176	Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy	https://ClinicalTrials.gov/show/NCT03673176	Recruiting	Stanford University	2021-12-30
NCT03670121	A Pilot Study to Assess Treatment of Patients With Homogeneous Emphysema Using Sequential Segmental Bronchoscopic Thermal Vapor Ablation (NEXT STEP)	https://ClinicalTrials.gov/show/NCT03670121	Active, not recruiting	Uptake Medical Technology, Inc.	2020-01-30
NCT03653104	Melodica Orchestra for Dyspnea: Safety and Feasibility Pilot	https://ClinicalTrials.gov/show/NCT03653104	Active, not recruiting	VA Quality Enhancement Research Intiative	2019-12-31
NCT03636347	A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.	https://ClinicalTrials.gov/show/NCT03636347	Recruiting	Mereo BioPharma	2020-06-23
NCT03518177	Comparison of the Effectiveness of Home and Hospital-based PR in Candidate Patients With BLVR	https://ClinicalTrials.gov/show/NCT03518177	Completed	Istanbul Medipol University Hospital	2018-11-01
NCT03500731	Lung and Bone Marrow Transplantation for Lung and Bone Marrow Failure	https://ClinicalTrials.gov/show/NCT03500731	Recruiting	University of Pittsburgh	2023-12-31
NCT03480386	Home Pulmonary Rehabilitation for COPD	https://ClinicalTrials.gov/show/NCT03480386	Recruiting	Mayo Clinic	2022-02-28
NCT03474471	A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema.	https://ClinicalTrials.gov/show/NCT03474471	Recruiting	University Medical Center Groningen	2021-06-01
NCT03455686	Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease	https://ClinicalTrials.gov/show/NCT03455686	Recruiting	McMaster University	2023-03-31
NCT01233232	A 4 Week Study to Investigate the Safety and Tolerability of AZD5069 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT01233232	Completed	AstraZeneca	2011-03-31
NCT01220908	Evaluation of the PneumRx Lung Volume Reduction Coil to Treat Emphysema	https://ClinicalTrials.gov/show/NCT01220908	Completed	PneumRx, Inc.	2011-03-31
NCT01217671	International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema	https://ClinicalTrials.gov/show/NCT01217671	Completed	Kamada, Ltd.	2014-11-30
NCT01213043	Safety and Pharmacokinetics of Alpha-1 Proteinase Inhibitor in Subjects With Alpha1-Antitrypsin Deficiency	https://ClinicalTrials.gov/show/NCT01213043	Completed	Grifols Therapeutics LLC	2012-01-31
NCT02022683	To Improve Lung Function and Symptoms for Emphysema Patients Using Zephyr Valves	https://ClinicalTrials.gov/show/NCT02022683	Completed	Pulmonx Corporation	2017-01-20
NCT01181466	AeriSeal® System for Lung Volume Reduction in Patients With Advanced Emphysema	https://ClinicalTrials.gov/show/NCT01181466	Completed	Aeris Therapeutics	2011-05-31
NCT01110252	Safety Study of Cell Therapy to Treat Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT01110252	Completed	UPECLIN HC FM Botucatu Unesp	2010-10-31
NCT01102712	Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction	https://ClinicalTrials.gov/show/NCT01102712	Completed	Uptake Medical Corp	2010-12-31
NCT01101958	A Study of the Use of Chartis System to Optimize Subject Selection for Endobronchial Lung Volume Reduction (ELVR)	https://ClinicalTrials.gov/show/NCT01101958	Completed	Pulmonx Corporation	2013-03-31
NCT01077102	Eccentric Exercise Training as Novel Rehabilitation for Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT01077102	Completed	McGill University Health Centre/Research Institute of the McGill University Health Centre	2012-12-31
NCT01051258	AeriSeal System for Lung Volume Reduction	https://ClinicalTrials.gov/show/NCT01051258	Completed	Aeris Therapeutics	2011-08-31
NCT01041586	Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction	https://ClinicalTrials.gov/show/NCT01041586	Completed	Uptake Medical Corp	2011-01-31
NCT00884962	A Dose Ranging Study of the Aeris Polymeric Lung Volume Reduction (PLVR) System in Patients With Advanced Upper Lobe Predominant Emphysema	https://ClinicalTrials.gov/show/NCT00884962	Completed	Aeris Therapeutics	2010-05-31
NCT00825578	Use of Endobronchial Valves in Non-Upper Lobe Heterogeneous Emphysema	https://ClinicalTrials.gov/show/NCT00825578	Completed	Royal Brompton & Harefield NHS Foundation Trust	2010-12-31
NCT03733470	Hypoxic Pulmonary Vasoconstriction Pilot Study	https://ClinicalTrials.gov/show/NCT03733470	Completed	University of Iowa	2014-01-13
NCT03244059	Belimumab Treatment of Emphysema Patients With Anti-GRP78 Autoantibodies	https://ClinicalTrials.gov/show/NCT03244059	Recruiting	University of Alabama at Birmingham	2020-07-31
NCT01983241	Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)	https://ClinicalTrials.gov/show/NCT01983241	Recruiting	Grifols Therapeutics LLC	2023-11-30
NCT01953523	Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions	https://ClinicalTrials.gov/show/NCT01953523	Completed	Cell Surgical Network Inc.	2016-12-31
NCT00720226	Efficacy of Losartan in Preventing Progression of COPD	https://ClinicalTrials.gov/show/NCT00720226	Completed	Johns Hopkins University	2014-08-31
NCT00684892	Safety and Feasibility Study of the Chartis System With Heterogeneous Emphysema Prior to Endobronchial Lung Volume Reduction (ELVR)	https://ClinicalTrials.gov/show/NCT00684892	Completed	Pulmonx Corporation	2008-11-30
NCT00683722	PROCHYMALâ„¢ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT00683722	Completed	Mesoblast, Ltd.	2009-03-09
NCT00680056	Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients	https://ClinicalTrials.gov/show/NCT00680056	Completed	Federal University of São Paulo	2008-12-31
NCT00670007	Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.	https://ClinicalTrials.gov/show/NCT00670007	Completed	CSL Behring	2014-09-30
NCT00630227	Biologic Lung Volume Reduction (BLVR) Phase 2 Homogeneous Study	https://ClinicalTrials.gov/show/NCT00630227	Completed	Aeris Therapeutics	2009-12-31
NCT00566839	Randomized Comparison of Awake Nonresectional Versus Nonawake Resectional Lung Volume Reduction Surgery	https://ClinicalTrials.gov/show/NCT00566839	Completed	University of Rome Tor Vergata	NA
NCT00563641	Very Early Surfactant and NCPAP for Premature Infants With RDS	https://ClinicalTrials.gov/show/NCT00563641	Completed	Colombian Neonatal Research Network	NA
NCT00517998	Israeli Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study	https://ClinicalTrials.gov/show/NCT00517998	Completed	Aeris Therapeutics	2009-03-31
NCT00515164	US Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study	https://ClinicalTrials.gov/show/NCT00515164	Completed	Aeris Therapeutics	2008-04-30
NCT00475007	Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema	https://ClinicalTrials.gov/show/NCT00475007	Completed	Spiration, Inc.	2011-02-28
NCT00435253	US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study	https://ClinicalTrials.gov/show/NCT00435253	Completed	Aeris Therapeutics	2009-06-30
NCT00424528	Efficacy Safety Study of Arformoterol/Tiotropium Combination Versus Either Therapy Alone in Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT00424528	Completed	Sunovion	2007-10-31
NCT00413205	TESRA: (Treatment of Emphysema With a Gamma-Selective Retinoid Agonist)	https://ClinicalTrials.gov/show/NCT00413205	Completed	Hoffmann-La Roche	2010-05-31
NCT00406705	The Effect of Breathing Helium-Hyperoxia During Pulmonary Rehabilitation in Patients With COPD	https://ClinicalTrials.gov/show/NCT00406705	Completed	University of Alberta	NA
NCT00373932	Real-Time Support for Exercise Persistence in COPD	https://ClinicalTrials.gov/show/NCT00373932	Completed	University of Washington	2008-12-31
NCT00347659	US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study	https://ClinicalTrials.gov/show/NCT00347659	Completed	Aeris Therapeutics	2006-12-31
NCT00269087	GW815SF For Chronic Obstructive Pulmonary Disease (Chronic Bronchitis, Emphysema)	https://ClinicalTrials.gov/show/NCT00269087	Completed	GlaxoSmithKline	2006-10-01
NCT00263887	Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE)	https://ClinicalTrials.gov/show/NCT00263887	Completed	Grifols Therapeutics LLC	2007-01-31
NCT00261833	Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency	https://ClinicalTrials.gov/show/NCT00261833	Completed	CSL Behring	2012-09-30
NCT00250679	Safety and Efficacy of Arformoterol Tartrate Inhalation Solution in Subjects With Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT00250679	Completed	Sunovion	2007-10-31
NCT00232674	Efficacy Study of the Effect of Budesonide on Emphysema	https://ClinicalTrials.gov/show/NCT00232674	Completed	AstraZeneca	NA
NCT00207337	Exhale (R) Stent for Emphysema	https://ClinicalTrials.gov/show/NCT00207337	Completed	Broncus Technologies	2006-05-31
NCT00188825	Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant	https://ClinicalTrials.gov/show/NCT00188825	Completed	University Health Network, Toronto	2007-10-31
NCT00181207	Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation	https://ClinicalTrials.gov/show/NCT00181207	Completed	Johns Hopkins University	2007-11-30
NCT00175565	Inhaled Steroid Reduces Systemic Inflammation in COPD	https://ClinicalTrials.gov/show/NCT00175565	Completed	University of British Columbia	NA
NCT00129584	Endobronchial Valve for Emphysema Palliation Trial (VENT)	https://ClinicalTrials.gov/show/NCT00129584	Completed	Emphasys Medical	NA
NCT00145548	Pilot Study of the Spiration IBVâ„¢ System	https://ClinicalTrials.gov/show/NCT00145548	Completed	Spiration, Inc.	2007-08-31
NCT00123422	Innovation in Pulmonary Rehabilitation	https://ClinicalTrials.gov/show/NCT00123422	Completed	VA Office of Research and Development	2009-08-31
NCT00106080	Improving the Quality of End-of-Life Communication for Patients With Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT00106080	Completed	VA Office of Research and Development	2008-05-31
NCT00104637	Sildenafil for Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT00104637	Completed	Kawut, Steven, MD	2008-11-30
NCT00085852	US 10 mL Bronchoscopic Lung Volume Reduction (BLVR) Phase 1 Emphysema Study - Initial Formulation	https://ClinicalTrials.gov/show/NCT00085852	Completed	Aeris Therapeutics	2006-10-31
NCT00064415	To Evaluate the Long-term Safety of (R,R)-Formoterol in Subjects With COPD	https://ClinicalTrials.gov/show/NCT00064415	Completed	Sunovion	2004-12-31
NCT00064402	Determine the Safety and Efficacy of (R,R)-Formoterol in the Treatment of Subjects With COPD	https://ClinicalTrials.gov/show/NCT00064402	Completed	Sunovion	2004-03-31
NCT00051792	Yoga for Treating Shortness of Breath in Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT00051792	Completed	National Center for Complementary and Integrative Health (NCCIH)	NA
NCT00034112	Efficacy of Osteopathic Manipulation in Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT00034112	Completed	National Center for Complementary and Integrative Health (NCCIH)	NA
NCT00018525	Lung Volume Reductions Surgery (LVRS) Study	https://ClinicalTrials.gov/show/NCT00018525	Completed	VA Office of Research and Development	NA
NCT00013156	Cost-Effectiveness of Lung Volume Reduction Surgery	https://ClinicalTrials.gov/show/NCT00013156	Completed	VA Office of Research and Development	NA
NCT00000621	Feasibility of Retinoic Acid Treatment in Emphysema (FORTE)	https://ClinicalTrials.gov/show/NCT00000621	Completed	National Heart, Lung, and Blood Institute (NHLBI)	2004-12-31
NCT00000606	National Emphysema Treatment Trial (NETT)	https://ClinicalTrials.gov/show/NCT00000606	Completed	National Heart, Lung, and Blood Institute (NHLBI)	2005-12-31
NCT00000573	Emphysema: Physiologic Effects of Nutritional Support	https://ClinicalTrials.gov/show/NCT00000573	Completed	National Heart, Lung, and Blood Institute (NHLBI)	NA

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03049202	BROnchoalveolar Investigations of Never-smokers With Chronic Obstruction From the Swedish CardioPulmonary bioImage Study	https://ClinicalTrials.gov/show/NCT03049202	Recruiting	Karolinska Institutet	2020-06-01
NCT03010592	Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD	https://ClinicalTrials.gov/show/NCT03010592	Recruiting	Royal Brompton & Harefield NHS Foundation Trust	2020-01-31
NCT03010566	Lung Volume Reduction Coil Microbiome Study	https://ClinicalTrials.gov/show/NCT03010566	Recruiting	Royal Brompton & Harefield NHS Foundation Trust	2020-01-31
NCT02898272	SCCOR Minorities Observational Study	https://ClinicalTrials.gov/show/NCT02898272	Enrolling by invitation	University of Pittsburgh	2019-08-31
NCT02879773	Computed Tomography Assessment of Regional Ventilation (CURVE)	https://ClinicalTrials.gov/show/NCT02879773	Completed	Heart of England NHS Trust	2018-06-01
NCT02815683	Bronchoscopic EmphysemA Treatment in THE NetherLands	https://ClinicalTrials.gov/show/NCT02815683	Recruiting	University Medical Center Groningen	2021-09-30
NCT02810327	Alpha-1 Carrier Genomics Study	https://ClinicalTrials.gov/show/NCT02810327	Completed	Medical University of South Carolina	2017-04-30
NCT02719184	Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease)	https://ClinicalTrials.gov/show/NCT02719184	Active, not recruiting	Boehringer Ingelheim	2021-03-29
NCT02627872	Clinical & Systems Medicine Investigations of Smoking-related Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT02627872	Active, not recruiting	Karolinska Institutet	2020-12-31
NCT02238327	Longitudinal Evaluation of HIV-associated Lung Disease Phenotypes	https://ClinicalTrials.gov/show/NCT02238327	Active, not recruiting	University of Pittsburgh	2020-09-30
NCT02232841	Electrical Impedance Imaging of Patients on Mechanical Ventilation	https://ClinicalTrials.gov/show/NCT02232841	Completed	Colorado State University	2016-08-31
NCT01305668	Rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) Patients With Emphysema	https://ClinicalTrials.gov/show/NCT01305668	Completed	Villa Pineta Hospital	2012-12-31
NCT01302587	A Study to Evaluate the Integrated Dose Counter on an Albuterol Hydrofluoroalkane (HFA) Metered Dose Inhaler (MDI)	https://ClinicalTrials.gov/show/NCT01302587	Completed	Teva Pharmaceutical Industries	2011-06-30
NCT02056158	HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Endothelium	https://ClinicalTrials.gov/show/NCT02056158	Recruiting	Weill Medical College of Cornell University	2021-08-31
NCT01969344	Study of COPD Subgroups and Biomarkers	https://ClinicalTrials.gov/show/NCT01969344	Active, not recruiting	University of North Carolina, Chapel Hill	2022-05-31
NCT01515709	Is the Short Physical Performance Battery a Useful Outcome Measure in Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT01515709	Completed	Royal Brompton & Harefield NHS Foundation Trust	2013-09-30
NCT01507415	Do the SPPB and 4-metre Gait Speed Predict Hospital Readmission in Patients Hospitalised for Acute Exacerbation if COPD?	https://ClinicalTrials.gov/show/NCT01507415	Completed	Royal Brompton & Harefield NHS Foundation Trust	2013-02-28
NCT01476995	Prognostic Indicators as Provided by the EPIC ClearView	https://ClinicalTrials.gov/show/NCT01476995	Completed	Epic Research & Diagnostics, Inc.	2011-06-30
NCT01393379	ELVR in PH Patients With Severe Emphysema	https://ClinicalTrials.gov/show/NCT01393379	Completed	Heidelberg University	2014-05-31
NCT04435327	Lung Damage Caused by SARS-CoV-2 Pneumonia (COVID-19)	https://ClinicalTrials.gov/show/NCT04435327	Recruiting	University of Milano Bicocca	2021-04-30
NCT04012359	Description of Bullous Emphysema Using Lung Ultrasound and Comparison to the Characteristics of Pneumothorax	https://ClinicalTrials.gov/show/NCT04012359	Recruiting	University Hospital, Rouen	2021-07-31
NCT03657121	Mortality and Symptom Burden Post Hospitalisation With COPD	https://ClinicalTrials.gov/show/NCT03657121	Active, not recruiting	Northumbria Healthcare NHS Foundation Trust	2020-08-31
NCT01229020	Distribution of Regional Lung Function by Vibration Response Imaging	https://ClinicalTrials.gov/show/NCT01229020	Completed	Deep Breeze	2006-01-31
NCT01192932	Effects of Nycthemeral Variations on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent in Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT01192932	Completed	Erasme University Hospital	2011-06-30
NCT01142531	Effects of Bronchodilation on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent.	https://ClinicalTrials.gov/show/NCT01142531	Completed	Erasme University Hospital	2011-06-30
NCT01121367	Study on Phenotypic Characterization of Combined Pulmonary Fibrosis and Emphysema	https://ClinicalTrials.gov/show/NCT01121367	Completed	Beijing Chao Yang Hospital	2011-06-30
NCT00974064	The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and Disease	https://ClinicalTrials.gov/show/NCT00974064	Active, not recruiting	Weill Medical College of Cornell University	2020-03-31
NCT00870857	Prevalence and Pathogenesis of Lung Disease in a Large HIV Cohort-coordinating Center	https://ClinicalTrials.gov/show/NCT00870857	Completed	University of Pittsburgh	2013-10-31
NCT00869544	Pneumocystis in Pathogenesis of HIV-associated Emphysema	https://ClinicalTrials.gov/show/NCT00869544	Completed	University of Pittsburgh	2010-09-30
NCT01326572	Lung HIV Disease in a Large Cohort-Pitt	https://ClinicalTrials.gov/show/NCT01326572	Completed	University of Pittsburgh	2016-01-31
NCT02827721	Evaluation of Novel Lung Function Parameters in Patients With Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT02827721	Recruiting	Universitätsmedizin Mannheim	2020-11-30
NCT02611947	CT Indexes of Emphysema and Airways in Healthy Volunteers: Normal Values; Relations With Gender, Height and Weight	https://ClinicalTrials.gov/show/NCT02611947	Completed	Erasme University Hospital	2011-06-30
NCT00757120	Biomarkers and Genetic Factors Related to Emphysema	https://ClinicalTrials.gov/show/NCT00757120	Completed	Washington University School of Medicine	2011-09-30
NCT00725309	Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT00725309	Completed	Washington University School of Medicine	2017-12-31
NCT00675454	Evaluating the Effects of Surgical and Non-Surgical Treatment Options in People With Emphysema	https://ClinicalTrials.gov/show/NCT00675454	Enrolling by invitation	Washington University School of Medicine	2020-12-31
NCT00608764	Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT00608764	Active, not recruiting	Brigham and Women’s Hospital	2022-12-31
NCT00570544	Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema	https://ClinicalTrials.gov/show/NCT00570544	Completed	Gelb, Arthur F., M.D.	NA
NCT00528944	Single-Breath Measurement Underestimates Ventilatory Volume According to Emphysema Severity	https://ClinicalTrials.gov/show/NCT00528944	Completed	Columbia University	2008-07-31
NCT00298389	Macrophage Phagocytosis in COPD	https://ClinicalTrials.gov/show/NCT00298389	Completed	Imperial College London	2010-12-31
NCT00224198	Evaluation of the Lungs of Individuals With Lung Disease	https://ClinicalTrials.gov/show/NCT00224198	Completed	Weill Medical College of Cornell University	2012-09-30
NCT00147095	Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary Disease	https://ClinicalTrials.gov/show/NCT00147095	Completed	Imperial College London	2005-02-28
NCT00147082	Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)	https://ClinicalTrials.gov/show/NCT00147082	Completed	Imperial College London	2004-12-31
NCT00147069	Leukocyte Function in Asthma and COPD	https://ClinicalTrials.gov/show/NCT00147069	Completed	Imperial College London	2007-04-30
NCT00147017	Regulation of the Release of Inflammatory Mediators From Lung Macrophages.	https://ClinicalTrials.gov/show/NCT00147017	Completed	Imperial College London	2010-12-31
NCT00001462	Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals	https://ClinicalTrials.gov/show/NCT00001462	Completed	National Institutes of Health Clinical Center (CC)	NA
NCT00005717	Medication Adherence in COPD–A Self-Regulation Study	https://ClinicalTrials.gov/show/NCT00005717	Completed	National Heart, Lung, and Blood Institute (NHLBI)	NA
NCT00005292	Alpha1-antitrypsin Deficiency Registry	https://ClinicalTrials.gov/show/NCT00005292	Completed	National Heart, Lung, and Blood Institute (NHLBI)	NA
NCT00005279	Tucson Epidemiology Study of Chronic Obstructive Lung Diseases	https://ClinicalTrials.gov/show/NCT00005279	Completed	National Heart, Lung, and Blood Institute (NHLBI)	NA
NCT00005123	Honolulu Heart Program	https://ClinicalTrials.gov/show/NCT00005123	Completed	National Heart, Lung, and Blood Institute (NHLBI)	NA

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04161235	Post-Market Clinical Evaluation of the Zephyr Valve 5.5-LP EBV	https://ClinicalTrials.gov/show/NCT04161235	Enrolling by invitation	Pulmonx Corporation	2021-04-30
NCT02803242	COPD Patient-Powered Research Network	https://ClinicalTrials.gov/show/NCT02803242	Recruiting	COPD Foundation	2025-01-31
NCT03755505	The Microbiome of Sputum, Urine and Feces in Healthy Persons and Chronic Obstructive Pulmonary Disease (COPD) Patients	https://ClinicalTrials.gov/show/NCT03755505	Recruiting	Asan Medical Center	2019-03-31
NCT03318406	Post-Market BTVA Registry	https://ClinicalTrials.gov/show/NCT03318406	Recruiting	Uptake Medical Technology, Inc.	2024-12-01
NCT03263130	Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap	https://ClinicalTrials.gov/show/NCT03263130	Recruiting	Gelb, Arthur F., M.D.	2022-01-01
NCT04186546	Zephyr Valve Registry (ZEVR)	https://ClinicalTrials.gov/show/NCT04186546	Enrolling by invitation	Pulmonx Corporation	2021-12-31
NCT03680495	Steroid Resistance During COPD Exacerbations With Respiratory Failure	https://ClinicalTrials.gov/show/NCT03680495	Recruiting	University of Colorado, Denver	2020-03-31
NCT00307281	Emphysema/COPD Research Registry	https://ClinicalTrials.gov/show/NCT00307281	Recruiting	University of Pittsburgh	2030-07-31